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Objective:To evaluate the antidiabetic potential of methanolic extract of Albizia odoratissima Benth.bark in alloxan induced diabetic mice.Methods:Group-Ⅰ(normal control) mice received only basal diet without any treatment.In Group-Ⅱ(Diabetic control) mice,diabetes was induced by alloxan(150 mg/kg i.p.) and received only Tween 80.5%v/v in normal saline. Group-Ⅲand Group-Ⅳmice received metformin(10 mg/kg) and gliclazide(10 mg/kg) as standard drugs.Group-ⅤandⅥmice received methanolic bark extract of Albizia odoratissima at doses of 250 and 500 mg/kg body weight p.o.,respectively.Results:The results of the study indicates that Albizia odoratissima bark extract significantly(P<0.01) reduced the blood sugar level.The bark extract also significantly reduced the levels of serum cholesterol,triglycerides, serum glutamic-oxaloacetic transaminase,serum glutamic-pyruvic transaminase,alkaline phosphatase and decreases level of total proteins in alloxan induced diabetic mice.Conclusions: Methanolic extract of Albizia odoratissima has protective effects on the protection of vital tissues(pancreas,kidney,liver,heart and spleen),thereby reducing the causation of diabetes in experimental animals.
Objective: To evaluate the antidiabetic potential of methanolic extract of Albizia odoratissima Benth. Bark in alloxan induced diabetic mice. Methods: Group-I (normal control) mice received only basal diet without any treatment. In Group-II (Diabetic control) mice, Group-III and Group-IV mice received metformin (10 mg / kg) and gliclazide (10 mg / kg) as standard drugs . Group-Ⅴ and Ⅵ mice received methanolic bark extract of Albizia odoratissima at doses of 250 and 500 mg / kg body weight po, respectively. Results: The results of the study indicate that Albizia odoratissima bark extract significantly (P <0.01) reduced the blood sugar level The bark extract also significantly reduced the levels of serum cholesterol, triglycerides, serum glutamic-oxaloacetic transaminase, serum glutamic-pyruvic transaminase, alkaline phosphatase and reduction level of total proteins in alloxan induced diabetic mice. Conclusions : Methanolic extract of Albizia odoratissima has protective effects on the protection of vital tissues (pancreas, kidney, liver, heart and spleen), thereby reducing the causation of diabetes in experimental animals.