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目的:观察动物类中药材蜣螂乙醇提取物的抗炎作用。方法:采用二甲苯诱发的小鼠耳廓肿胀实验、鸡蛋清诱发的小鼠足趾肿胀实验、乙酸所致的小鼠腹腔毛细血管通透性增加实验和角叉菜胶诱发大鼠胸膜炎等炎症模型,观察动物类中药材蜣螂乙醇提取物的抗炎活性;测定胸膜炎大鼠的胸腔渗出液中总蛋白含量、血清中前列腺素E2(PGE2)与肿瘤坏死因子(TNF-α)含量,探讨其抗炎作用机制。结果:低、中、高剂量的蜣螂乙醇提取物能显著抑制二甲苯所致的耳廓肿胀、鸡蛋清所致的足趾肿胀以及醋酸所致的腹腔毛细血管通透性增加,并能有效降低胸膜炎大鼠的胸腔渗出液中蛋白含量、血清中前列腺素E2(PGE2)与肿瘤坏死因子(TNF-α)含量。结论:动物类中药材蜣螂的乙醇提取物具有抗炎作用,其作用机制与降低PGE2和TNF-α含量有关。
OBJECTIVE: To observe the anti-inflammatory effects of ethanol extracts from the Chinese medicinal herb dung beetle. Methods: The auricle swelling of mice induced by xylene, the mouse toe swelling induced by egg white, the increase of peritoneal capillary permeability induced by acetic acid and the inflammation of carrageenan-induced pleurisy in rats Model to observe the anti-inflammatory activity of ethanol extract from the Chinese medicinal herb dung beetle. The content of total protein, the content of prostaglandin E2 (PGE2) and tumor necrosis factor (TNF-α) Explore its anti-inflammatory mechanism. RESULTS: Low, medium and high doses of ethanolic extract of dung beetle could significantly inhibit xylene-induced auricle swelling, egg-induced toe swelling and increased peritoneal capillary permeability caused by acetic acid, and were effective Reduce pleural effusion rat pleural effusion protein content, serum prostaglandin E2 (PGE2) and tumor necrosis factor (TNF-α) content. Conclusion: The ethanol extracts from the Chinese herb Dung beetle have anti-inflammatory effects, and their mechanism is related to the decrease of PGE2 and TNF-α contents.