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为探讨人乳头状瘤病毒 (HPV)感染在食管癌发病中的作用 ,采用荧光定量聚合酶链反应对河北省高发区食管癌、癌前病变、正常食管组织和低发区食管癌组织中人乳头状瘤病毒 (HPV1 6、1 8)进行检测。结果显示 ,高发区食管癌组织 HPV1 6、1 8DNA阳性率为 38.7% ,癌前病变为 2 5 % ,正常食管组织为 2 .5 % ,低发区食管癌组织为2 0 %。高发区食管癌和癌前病变与正常食管组织 HPV1 6、1 8感染率相比差异具有显著性 (P<0 .0 1) ;低发区食管癌组织 HPV1 6、1 8感染率与高发区正常食管组织相比差异具有显著性 (P<0 .0 1) ;低发区食管癌组织 HPV1 6、1 8感染率低于高发区食管癌组织 ,但差异无显著性 (P>0 .0 5 )。提示河北省食管癌高低发地区食管癌组织、高发区食管癌前病变组织中均存在较高的人乳头状瘤病毒感染率 ,为食管癌发病的重要因素之一
In order to explore the role of human papillomavirus (HPV) in the pathogenesis of esophageal cancer, fluorescence quantitative polymerase chain reaction (PCR) was used to detect esophageal cancer, precancerous lesions, normal esophageal tissues and low esophageal cancer tissues in Hebei province Papilloma virus (HPV1 6,1 8) for testing. The results showed that HPV16, 18 DNA positive rate of esophageal cancer tissue in high incidence area was 38.7%, precancerous lesions was 25%, normal esophageal tissue was 2.5%, low incidence esophageal cancer tissue was 20%. High incidence of esophageal cancer and precancerous lesions and normal esophageal HPV1 6,1 8 infection rate compared to the difference was significant (P <0.01); low incidence of esophageal cancer HPV16, 18 infection rate and high incidence The difference of HPV16 / 18 in esophageal cancer was lower than that in high incidence esophageal cancer, but the difference was not significant (P> 0.05) 5). Prompt esophageal cancer in Hebei Province esophageal cancer area, high incidence of esophageal precancerous lesions are higher in human papilloma virus infection rate, the incidence of esophageal cancer is one of the important factors