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利用兔大脑中动脉阻断(MCAO)模型,用放射免疫法检测脑皮质和血浆β-内啡肽样免疫活性物质的含量,并分别测定脑组织丙二醛(MDA)、Ca~(2+)及H_2O含量。实验动物随机分成3组:对照组(正常和假手术对照)、脑缺血后4h及24h。结果发现脑组织β-内啡肽、MDA、Ca~(2+)和H_2O含量均显著增加(P<0.05),且脑缺血后24h组高于4h组(P<0.05)。同时还发现β-内啡肽与脑组织H_2O、Ca~(2+)、MDA含量之间呈正相关,结果说明脑缺血后β-内啡肽含量的增加,参与了脑缺血脑损害,其机理可能与Ca~(2+)和自由基反应有关。
The levels of β-endorphin-like immunoreactive substance in cerebral cortex and plasma were detected by radioimmunoassay using the middle cerebral artery occlusion (MCAO) model in rabbits. The contents of malondialdehyde (MDA), Ca 2+ ) And H_2O content. Experimental animals were randomly divided into 3 groups: control group (normal and sham control), 4h and 24h after cerebral ischemia. The results showed that the contents of β-endorphin, MDA, Ca 2+ and H 2 O in brain tissue increased significantly (P <0.05), and were higher in 24h group than those in 4h group (P <0.05). Also found that β-endorphin and brain tissue H_2O, Ca ~ (2 +), MDA content was positively correlated, the results show that after cerebral ischemia increased β-endorphin, involved in cerebral ischemia and brain damage, The mechanism may be Ca ~ (2+) and free radical reactions.