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抗肿瘤药brostallicin盐酸盐(PNU-166196A)为一种合成的第二代DNA小沟结合剂(minor groovebinder,MGB),其结构是在偏端霉素A(distamycinA)的主链上共价结合了α-溴代丙烯酰基。Brostalli-cin在高浓度谷胱甘肽和(或)谷胱甘肽S-转移酶(GST)存在的条件下具有活性,不受DNA错配修复
The antitumor brostallicin hydrochloride (PNU-166196A) is a synthetic second-generation minor groove binder (MGB) whose structure is covalently linked to the backbone of distamycin A The α-bromoacryloyl group is bound. Brostalli-cin is active in the presence of high concentrations of glutathione and / or glutathione S-transferase (GST), free from DNA mismatch repair