前列腺素Ｅ1作为具有广泛生物活性的前列腺素衍生物 ,近年来在临床上的应用日益广泛。静脉滴注前列腺素Ｅ1有扩张血管、抑制血小板聚集、抗动脉粥样硬化、降低肺动脉压的作用[1,2 ] ,但因其局部刺激作用较强 ,在治疗剂量下常引起输注该药的血管明显扩张、发红、感疼痛 ,使患者 Prostaglandin E1, as a prostaglandin derivative with a wide range of biological activity, has been widely used clinically in recent years. Intravenous injection of prostaglandin E1 has dilated blood vessels, inhibition of platelet aggregation, anti-atherosclerosis, decreased pulmonary arterial pressure [1,2], but because of its strong local stimuli, often caused at the therapeutic dose infusion of the drug The blood vessels significantly dilated, redness, a sense of pain, so that patients