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目的 :探讨突发性聋 (突聋 )患者的凝血、抗凝、纤溶系统的状况。方法 :检测了 42例突聋患者治疗前及2 3例治疗后 ,32例正常健康人血浆中部分凝血因子、抗凝、纤溶活性和血小板功能。结果 :42例突聋患者治疗前凝血活性、血小板功能增强 ,抗凝、纤溶活性降低。其中 2 3例突聋患者采用维生素、低分子右旋糖酐、能量合剂及扩血管、抗病毒药物等综合治疗 1个月后 ,凝血、抗凝活性和血小板功能与对照组比较无显著性差异 ( P >0 .0 5 ) ,但血浆 D-二聚体明显升高 ( P <0 .0 1)。结论 :突聋患者治疗前凝血和血小板功能增强 ,抗凝、纤溶活性降低 ,治疗后继发性纤溶活性增强 ,血栓形成是突聋发病的重要原因之一
Objective: To investigate the coagulation, anticoagulation and fibrinolytic system in patients with sudden deafness (sudden deafness). Methods: The plasma levels of some coagulation factors, anticoagulation, fibrinolytic activity and platelet function were measured in 42 cases of sudden deafness before treatment and after 23 cases of treatment. Results: 42 cases of sudden deafness patients before treatment, coagulation activity, enhanced platelet function, anticoagulant, fibrinolytic activity decreased. There was no significant difference in the coagulation, anticoagulant activity and platelet function between the control group and the 23 patients with sudden deafness after one month treatment with vitamins, low molecular weight dextran, energy mixture, vasodilators and antiviral drugs (P> 0.05), but plasma D-dimer was significantly higher (P <0.01). Conclusion: The patients with sudden deafness have better coagulation and platelet function, anticoagulant and fibrinolytic activity before treatment, secondary fibrinolytic activity after treatment, thrombosis is one of the important causes of sudden deafness