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目的探讨TSH、TG检测在术前甲状腺结节患者良恶性预测中的临床应用。方法回顾分析770例行甲状腺手术的甲状腺结节患者术前的TSH、TG水平和术后临床诊断等资料。然后按参考值将TSH、TG的阳性界限为≥4.94m IU/L和≥70 ng/m L,否则为阴性,将所有病例分为4组对比分析。结果发现甲状腺癌患者的术前血清TSH水平(5.96±4.81)m IU/L明显高于良性甲状腺结节患者(3.73±3.62)m IU/L,P<0.01;甲状腺癌患者术前TG水平(111.23±249.64)ng/L和良性甲状腺结节患者术前TG水平(86.79±178.85)ng/L比较,差异无统计学意义(P>0.05);甲状腺癌患者的TSH和TG无相关性,P>0.05;TSH、TG双阳性组中甲状腺癌比例最高,和其他三组相比差异具有统计学意义(P<0.05)。结论 TSH、TG同时增高呈阳性可作为判断甲状腺肿瘤良恶性的一个辅助指标。
Objective To investigate the clinical application of TSH and TG in the prediction of benign and malignant thyroid nodules. Methods A retrospective analysis of 770 cases of thyroid nodules in patients with thyroid nodules preoperative TSH, TG levels and postoperative clinical diagnosis and other data. The positive limits of TSH and TG were ≥4.94 m IU / L and ≥70 ng / m L according to the reference values, otherwise negative. All the cases were divided into four groups for comparative analysis. The results showed that preoperative serum TSH level (5.96 ± 4.81) m IU / L in thyroid cancer patients was significantly higher than that in benign thyroid nodules (3.73 ± 3.62) m IU / L, P <0.01; thyroid cancer patients with preoperative serum TG levels 111.23 ± 249.64) ng / L and benign thyroid nodules, there was no significant difference between preoperative TG levels (86.79 ± 178.85) ng / L and thyroid cancer patients (P> 0.05) > 0.05. The highest proportion of thyroid cancer was found in TSH and TG double positive group, which was significantly different from the other three groups (P <0.05). Conclusions TSH, TG positive at the same time can be used as a secondary indicator to judge benign and malignant thyroid tumors.