志贺菌具有侵袭豚鼠角膜上皮细胞并向邻近细胞播散的能力,从而引起豚鼠角结膜炎,由此为测定志贺菌株的毒力以及志贺菌菌苗的保护效力与免疫原性提供了一个良好的模型系统。作者使用这一模型测定了不同接种途径(粘膜免疫与非肠道免疫)、免疫次数和时间(基础免疫与加强免疫)以及抗原形式(减毒活菌苗或O抗原-蛋白结合物)在抗志贺菌感染中的免疫力中的作用。 Shigella has the ability to invade guinea pig corneal epithelial cells and disseminate to neighboring cells, resulting in guinea pig keratoconjunctivitis, thus providing a measure of the virulence of the Shigella strains as well as the protective efficacy and immunogenicity of the Shigella vaccine A good model system. The authors used this model to determine the effect of different routes of vaccination (mucosal and parenteral immunizations), the number and timing of immunizations (both basal and booster), and antigenic forms (live attenuated vaccine or O antigen-protein conjugate) Shigella infection in the role of immunity.