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目的 探讨失神性癫痫持续发作的病理生理机制。 方法 采用C -fos基因探针原位杂交法在γ -羟丁酸诱发的大鼠失神性癫痫持续发作模型上 ,观察癫痫持续发作后不同时间丘脑各核团中C -fos基因表达的分布状况 ,用C -fos基因阳性细胞密度作定量研究指标。 结果 失神性癫痫发作后 1 0min ,双侧丘脑室旁核内可见到低密度C -fos阳性细胞 ;3 0min时 ,高密度C -fos阳性细胞广泛分布于外侧缰核、室旁核、菱形核和丘脑板内核群。 结论 外侧缰核及丘脑中线和板内核群极可能涉及失神性癫痫发作的病理生理机制。
Objective To investigate the pathophysiological mechanism of deafness epilepsy. Methods C-fos gene probe in situ hybridization was used to observe the distribution of C-fos gene expression in various nuclei in the thalamus at different time points after epileptic seizures on γ-hydroxybutyrate-induced dementia epilepsy model , With C-fos gene positive cell density for quantitative study of indicators. Results Low densities of C-fos positive cells were found in the paraventricular nucleus of hypothalamus at 10 minutes after deafness epileptic seizure. At 30 minutes, high density C-fos positive cells were widely distributed in lateral habenula, paraventricular nucleus, rhombic nucleus And thalamic nucleus groups. Conclusions The pathological and physiological mechanisms of denervation seizures are most likely involved in lateral habenular nucleus, thalamic midline and platelet nucleus.