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目的 观察抗生素及抗凝药对腹膜的影响,探讨腹膜透析相关硬化性腹膜炎的因素.方法用小鼠建立腹膜透析实验模型,模拟腹膜透析常用的药物注入小鼠腹腔内,通过大体解剖和光镜组织学观察各种药物在不同时间腹膜结构的变化.结果 丁胺卡那霉素、头孢拉啶、头抱呋新(西力欣)、环丙沙星、肝素及尿激酶在用药2~4wk均使腹膜间皮细胞丧失,炎症细胞浸润、纤维细胞增生;在用药6~8wk更为显著.停药后这些改变不能完全恢复.结论腹膜透析常用的抗生素及抗凝药均有致腹膜硬化的作用,但程度不一,这对临床选药及腹膜功能的保护具有重要意义.
Objective To observe the effects of antibiotics and anticoagulants on the peritoneum and to explore the factors of peritoneal dialysis-related sclerosing peritonitis.Methods The peritoneal dialysis model was established in mice, and the drugs commonly used in peritoneal dialysis were injected into the peritoneal cavity of the mice. The gross anatomy and light microscopy The changes of peritoneal structure of various drugs at different time were observed.Results Amikacin, cefradine, cefotaxime, ciprofloxacin, heparin and urokinase were all in the range of 2 ~ 4wk Peritoneal mesothelial cells, loss of peritoneal mesothelial cells, infiltration of inflammatory cells and proliferation of fibroblasts.It is more obvious in the treatment of 6 ~ 8wk.It can not be completely recovered after stopping the treatment.Conclusion Peritoneal dialysis commonly used antibiotics and anticoagulants have caused peritoneal sclerosis, But to varying degrees, which is of great significance for the protection of clinical drug selection and peritoneal function.