众多研究提示维持性血液透析(MHD)患者普遍存在血红蛋白波动,且血红蛋白波动可明显增加MHD患者住院率、心血管事件发生率及猝死等并发症。血红蛋白波动由年龄、性别、EPO及铁剂等药物、住院、感染及透析等多因素所致。本文综述了血红蛋白波动的定义、影响因素及与患者预后的关系。 Numerous studies suggest that hemoglobin fluctuations are common in patients with maintenance hemodialysis (MHD) and fluctuations in hemoglobin may significantly increase complications such as hospitalization rates, cardiovascular events and sudden death in MHD patients. Hemoglobin fluctuations caused by age, gender, EPO and iron drugs, hospitalization, infection and dialysis and other factors. This article summarizes the definition of hemoglobin fluctuation, the influencing factors and the relationship with the prognosis of patients.