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目的:分析冠心病(CHD)患者的心理状况,探讨血清白介素-6(IL-6)与CHD并发抑郁的关系,为临床提供CHD并发抑郁干预治疗的依据。方法:对90例CHD患者进行ZUNG抑郁自评量表(SDS)评分,根据评分结果分为CHD伴有抑郁组(A组)与不伴抑郁组(B组)。用放射免疫法测定血清IL-6的水平,并记录年龄、性别、吸烟、文化程度、糖尿病、高血压病史及血脂水平等相关资料。结果:入选的CHD患者57.58%伴有不同程度的抑郁,其中轻度抑郁者24例(26.67%),中、重度抑郁者28例(31.11%)。男性患者57.79%伴有抑郁,女性患者57.89%伴有抑郁;男、女性CHD患者抑郁并存率之间的差异无统计学意义。A组患者血清IL-6的水平[M(P25,P75]为[0.04(0.01,0.06)]μg/L,B组患者为[0.02(0.01,0.05)]μg/L,A组高于B组,差异有统计学意义(P<0.05)。A组中、重度抑郁患者血清IL-6水平为[0.05(0.02,0.08)]μg/L高于轻度抑郁IL-6水平为[0.04(0.01,0.05)]μg/L,差异有统计学意义(P<0.05)。结论:CHD患者有较高的抑郁并存率,CHD伴有抑郁患者血清IL-6的水平明显高于不伴有抑郁患者,中、重度抑郁患者血清IL-6的水平明显高于轻度抑郁。CHD伴有抑郁是体内具有炎性反应的一个标志,也即炎性反应在CHD并发抑郁中起着一定的作用。
OBJECTIVE: To analyze the psychological status of patients with coronary heart disease (CHD) and to explore the relationship between serum interleukin-6 (IL-6) and depression complicated by CHD and to provide the basis for clinical intervention in treating CHD complicated with depression. Methods: Ninety patients with CHD were scored by ZUNG depression self-rating scale (SDS). According to the scores, they were divided into depression-related depression group (group A) and depression-free group (group B). Serum IL-6 levels were measured by radioimmunoassay and age, sex, smoking, education, diabetes mellitus, history of hypertension and blood lipid levels were recorded. Results: 57.58% of CHD patients were selected with varying degrees of depression. Among them, 24 were mild depression (26.67%) and 28 (31.11%) were moderate and severe depression. 57.79% of male patients with depression, 57.89% of female patients with depression; male and female CHD patients with depression coexistence between the difference was not statistically significant. The level of serum IL-6 in group A was [0.04 (0.01,0.06)] μg / L for M group and [0.02 (0.01,0.05)] μg / L for group B, (P <0.05) .In group A, the level of IL-6 in patients with major depression was higher than that of mild depression [0.05 (0.02,0.08)] μg / L, 0.01, 0.05)] μg / L, the difference was statistically significant (P0.05) .Conclusion: CHD patients have higher depression coexistence rate, CHD patients with depression serum IL-6 levels were significantly higher than those without depression Serum levels of IL-6 are significantly higher in patients with moderate to severe depression than in mild depression, and CHD with depression is a hallmark of an inflammatory reaction in vivo, meaning that inflammatory responses play a role in the co-occurrence of depression in patients with CHD.