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目的探讨阿司匹林对阻塞性睡眠呼吸暂停综合征(OSAS)患者血小板功能的影响。方法79例OSAS患者口服阿司匹林100mg/d,共2周,分别于服前及服后检测血小板数量、平均体积、分布宽度及花生四烯酸(AA)和二磷酸腺苷(ADP)诱导的血小板聚集率。结果治疗前后比,血小板数量增加,体积缩小,分布宽度减小,血小板聚集率下降,差异有统计学意义,P<0.01。结论阿司匹林100g/d可以抑制OSAS患者血小板功能,对于OSAS患者的心脑血管缺血性疾病的预防可能有意义。
Objective To investigate the effect of aspirin on platelet function in patients with obstructive sleep apnea syndrome (OSAS). Methods 79 patients with OSAS were given aspirin 100mg / d for 2 weeks. The number of platelets, the average volume, the distribution width and the concentrations of arachidonic acid (AA) and adenosine diphosphate (ADP) Aggregation rate. Results Before and after treatment, the number of platelets increased, the volume decreased, the distribution width decreased, and the platelet aggregation rate decreased, the difference was statistically significant (P <0.01). Conclusions Aspirin 100g / d can inhibit platelet function in patients with OSAS, and it may be of significance for the prevention of cardiovascular and cerebrovascular ischemic diseases in patients with OSAS.