WIN57273是一个新氟喹诺酮,有类似于环丙氟哌酸的结构,但区别在于它的喹诺酮核7-位是一个2,6-二甲基吡啶基,而不是哌嗪基。它对许多革兰氏阳性病原菌,包括甲氧西林敏感的或耐药的金萄菌,流行链球菌和粪肠球菌,以及庆大霉素敏感的或耐药的粪肠球菌,都有强的活性。但还没有研究它的杀菌活性和对氟喹诺酮耐药的革兰氏阳性细菌的活性。作者搜集了各个病原微生物 WIN57273 is a novel fluoroquinolone with a structure similar to that of ciprofloxacin except that its quinolone nucleus at the 7-position is a 2,6-dimethylpyridyl, not piperazinyl. It is potent against many Gram-positive pathogens, including methicillin-sensitive or resistant to the genus Xanthomonas, Streptococcus and Enterococcus faecalis, and gentamycin-susceptible or resistant Enterococcus faecalis active. However, its bactericidal activity and activity against fluoroquinolone-resistant Gram-positive bacteria have not been studied. The author collected a variety of pathogenic microorganisms