幽门螺杆菌感染是慢性胃炎、消化性溃疡的主要致病因素 ,并且与胃癌的发生有关。本文报告了幽门螺杆菌疫苗及其相关性研究的成果 ,包括细菌的分离培养、毒力基因分型、抗原的纯化及单克隆抗体的研制、动物模型的建立及其基因工程株的构建等 Helicobacter pylori infection is the main causative agent of chronic gastritis and peptic ulcer, and is related to the occurrence of gastric cancer. This article reports the results of studies on Helicobacter pylori vaccines and their relevance, including bacterial isolation and isolation, virulence genotyping, antigen purification and the development of monoclonal antibodies, establishment of animal models, and construction of genetically engineered strains