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目的 通过检测ACTH受体及其mRNA在人淋巴组织中的表达情况 ,寻求神经内分泌系统 免疫系统之间功能双向调节的形态学依据。方法 应用免疫组化SP法及核酸分子原位杂交法检测ACTH受体及其mRNA在人淋巴结、脾脏及肠道淋巴组织中的表达。结果 免疫组化显示ACTH受体在人各种淋巴组织中表达的阳性率为 82 .5 % ,与原位杂交阳性率 70 .0 %之间的差异无显著性。结论 人的免疫活性细胞不但可以表达ACTH受体蛋白 ,还可以合成其mRNA ,ACTH受体为神经内分泌系统 免疫系统网络共有的生物学语言媒介 ,内分泌源性的ACTH与免疫源性的ACTH都可以通过免疫细胞膜上的ACTH受体发挥对免疫系统的调节作用
OBJECTIVE: To investigate the morphological basis of the bi-directional regulation of the neuroendocrine system’s immune system by detecting the expression of ACTH receptor and its mRNA in human lymphoid tissues. Methods Immunohistochemical SP method and nucleic acid in situ hybridization were used to detect the expression of ACTH receptor and its mRNA in human lymph node, spleen and intestinal lymphoid tissue. Results Immunohistochemistry showed that the positive rate of ACTH receptor expression in various human lymphoid tissues was 82.5%, which was not significantly different from that of in situ hybridization 70.0%. CONCLUSION: Human immunocompetent cells can not only express ACTH receptor protein but also synthesize mRNA. ACTH receptor is a common biological language medium of neuroendocrine system immune system network. Both endocrine ACTH and immunogenic ACTH can be Through the immune cell membrane on the ACTH receptor play a regulatory role in the immune system