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目的探讨肿瘤相关钙信号转导蛋白2(Trop-2)在非小细胞肺癌(NSCLC)中的表达及意义。方法采用免疫组化法检测70例NSCLC手术标本、13例癌旁组织及32例肺部良性病变组织中Trop-2的表达,分析其表达与非小细胞肺癌临床病理特征的关系。结果 Trop-2在NSCLC组织中的阳性表达率明显高于正常肺组织及良性病变组织(40.0%vs.9.38%和8.33%)(P<0.01);Trop-2的阳性表达率随着TNM分期的升高而升高(P<0.05);Trop-2在有淋巴结转移者阳性表达率高于无淋巴结转移者(P<0.05)。Trop-2的阳性表达与患者年龄、性别、吸烟情况、病理类型、分化程度无关(P>0.05)。结论 Trop-2在NSCLC中有较高的表达率。其表达与淋巴结转移及TNM分期有关。
Objective To investigate the expression and significance of Trop-2 in non-small cell lung cancer (NSCLC). Methods The expression of Trop-2 in 70 cases of NSCLC, 13 cases of paracancerous tissues and 32 cases of benign lung lesions were detected by immunohistochemistry. The relationship between the expression of Trop-2 and the clinicopathological features of non-small cell lung cancer was analyzed. Results The positive rate of Trop-2 expression in NSCLC tissues was significantly higher than that in normal lung tissues and benign lesions (40.0% vs.9.38% and 8.33%, P <0.01) (P <0.05). The positive expression rate of Trop-2 in patients with lymph node metastasis was higher than those without lymph node metastasis (P <0.05). The positive expression of Trop-2 was not related to the patient’s age, sex, smoking status, pathological type and degree of differentiation (P> 0.05). Conclusion Trop-2 has a higher expression rate in NSCLC. Its expression is related to lymph node metastasis and TNM staging.