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本文作者测定了肝组织中酪氨酸氨基转移酶的活性,研究肝硬化时高酪氨酸血症的病理生理是否与此酶活性的改变有关。31例经腹腔镜检查,按肝组织学表现分成4组:①对照组10例,肝组织学正常;②肝中度脂肪变性组,25～50%的肝细胞有脂肪变,共6例;③进行性脂肪变性伴纤维化和/或酒精性肝炎组,共8例;④小结节性肝硬化组,共7例,每例患者均有失代偿性肝损害,伴黄疸、凝血酶原时间缩短、低白蛋白血症,其中3例有肝性脑病的症状。分别测定血浆酪氨酸浓度、肝
The authors determined the activity of tyrosine aminotransferase in liver tissue and investigated whether the pathophysiology of hypertyrosinemia during cirrhosis is associated with altered enzyme activity. 31 cases were diagnosed by laparoscopy according to liver histology were divided into 4 groups: ① control group of 10 patients with normal liver histology; ② moderate hepatic steatosis group, 25 to 50% of liver cells with steatosis, a total of 6 cases; ③ progressive steatosis with fibrosis and / or alcoholic hepatitis group, a total of 8 cases; ④ small nodular cirrhosis group, a total of 7 cases, each patient has decompensated liver damage, with jaundice, thrombin The original time shortening, hypoalbuminemia, of which 3 cases of hepatic encephalopathy symptoms. The plasma tyrosine concentration and liver were measured respectively