肺癌是发病率和死亡率增长最快、对人类健康和生命威胁最大的恶性肿瘤。虽然近年来采取了以手术为主的多学科综合治疗 ,但绝大多数患者还是或早或晚死于肺癌的局部复发或远处转移。肺癌转移过程包括侵袭、循环扩散、远处克隆和血管生成。肺癌侵袭涉及肺癌细胞附着、基质成分的 Lung cancer is the fastest growing morbidity and mortality, the most threatening human health and life-threatening cancer. Although surgery-based multidisciplinary treatment has been adopted in recent years, most patients die of local recurrence or distant metastasis of lung cancer sooner or later. Lung cancer metastasis includes invasion, circulatory spread, distant colonization and angiogenesis. Invasion of lung cancer involves attachment of lung cancer cells, matrix components