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治疗性血浆置换(therapeutic plasma exchange,TPE)能有效清除血清中的抗体及促炎性细胞因子等致病物质,并对患者免疫功能具有调节作用。急性视神经炎甲泼尼龙静滴(intravenous methylprednisolone,IVMP)3~5天视力恢复不明显或不宜继续用糖皮质激素治疗者可考虑应用TPE,但应注意过敏反应和电解质紊乱等不良事件的防范。TPE对急性视神经炎的确切疗效以及最佳治疗方案等问题,尚需进一步循证研究。
Therapeutic plasma exchange (TPE) can effectively remove the serum antibodies and proinflammatory cytokines and other pathogenic substances, and immune function in patients with regulation. Acute optic neuritis Intravenous methylprednisolone intravenous methylprednisolone (IVMP) 3 to 5 days visual acuity was not obvious or should not continue with glucocorticoid therapy may consider the application of TPE, but should pay attention to allergic reactions and electrolyte disturbances and other adverse events prevention. The exact effect of TPE on acute optic neuritis and the best treatment options and other issues, the need for further evidence-based research.