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目的 :探讨非对称性二甲基精氨酸(ADMA)在妊娠期糖尿病(GDM)患者中的变化及临床意义。方法 :伴或不伴GDM的孕妇各50例分别为GDM组和对照组,比较两组血清ADMA水平,并且分析ADMA水平与血糖变化、分娩方式、分娩时间及新生儿并发症的相关性。结果 :GDM组ADMA水平(4.2±0.8)较对照组显(2.3±0.6)著升高,并且ADMA水平与GDM患者空腹血糖、1h血糖、2h血糖水平呈正相关。ADMA水平与顺产呈负相关,与剖宫产率呈正相关;与产妇早产率呈正相关,与足月产率呈负相关,与新生儿并发症发生率呈正相关。结论 :血清ADMA的检测有助于GDM的诊断,并且有助于判断分娩方式及新生儿并发症的发生率。
Objective: To investigate the changes and clinical significance of asymmetric dimethylarginine (ADMA) in gestational diabetes mellitus (GDM). Methods: Fifty pregnant women with and without GDM were divided into GDM group and control group respectively. Serum ADMA level was compared between two groups. The correlation between ADMA level and blood glucose, mode of delivery, delivery time and neonatal complications were analyzed. Results: The level of ADMA in GDM group (4.2 ± 0.8) was significantly higher than that in control group (2.3 ± 0.6), and the level of ADMA was positively correlated with fasting blood glucose, 1h blood glucose and 2h blood glucose in GDM patients. ADMA level was negatively correlated with cesarean section and positively correlated with cesarean section rate. It was positively correlated with preterm birth rate, negatively correlated with full-term birth rate, and positively correlated with neonatal complication rate. Conclusion: The detection of serum ADMA contributes to the diagnosis of GDM, and helps to determine the mode of delivery and the incidence of neonatal complications.