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在氧化应激和衰老相关的病理条件下,4-羟基烃烯醛在体内的平衡态浓度升高。作为脂质过氧化的主要中间产物之一,4-羟基烃烯醛已被证明以浓度依赖的方式影响细胞周期事件。谷胱甘肽转移酶通过降低脂质过氧化过程中4-羟基烃烯醛的生成,或通过将4-羟基烃烯醛转变为与GSH的结合物来降低4-羟基烃烯醛的浓度。细胞内谷胱甘肽转移酶的超表达降低了4-羟基烃烯醛的浓度,并有效地防御了细胞的凋亡,这表明由这些氧化物质引起的细胞凋亡是4-羟基烃烯醛介导的。本文对4-羟基烃烯醛的信号转导作用以及谷胱甘肽转移酶对其的调控做一综述。
In the oxidative stress and aging-related pathological conditions, 4-hydroxy-alkenal in the body’s equilibrium concentration increased. As one of the major intermediates of lipid peroxidation, 4-hydroxyhydralin has been shown to affect cell cycle events in a concentration-dependent manner. Glutathione transferase decreases the concentration of 4-hydroxyoctoate by lowering the production of 4-hydroxyoctoate in the process of lipid peroxidation, or by converting 4-hydroxyoctoate into a conjugate with GSH. Overexpression of intracellular glutathione transferase decreased the concentration of 4-hydroxyocatechualdehyde and effectively protected the cells from apoptosis, indicating that apoptosis caused by these oxidative substances is 4-hydroxyhydralin Mediated. In this paper, the signal transduction of 4-hydroxyalkenal and its regulation by glutathione transferase are reviewed.