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目的 :初治成人急性非淋巴细胞白血病 (AL L )治疗缓解率相关因素分析。方法 :用 t检验和卡方检验对各种因素进行统计学处理。结果 :初诊时外周血白细胞 (WBC) <2 0× 10 9/ L组和 WBC 2 0× 10 9/ L～ 5 0× 10 9/ L组分别与 WBC >5 0× 10 9/ L组比较 ,缓解率均有显著性差异 (P<0 .0 1和 P<0 .0 5 ) ;根据初诊时血清中乳酸脱氢酶 (L DH )值 ,将 CR组与 PR组、CR组与 NR组两两比较 ,均有显著性差异 (P<0 .0 1)。低年龄组 (16岁～ 5 5岁 )治疗缓解率 (6 7.1% )大于高年龄组 (>5 5岁 )缓解率 (6 0 .4% ) ;初诊时外周血及骨髓 (BM)中原始 +(早 )幼稚细胞比例数低者治疗缓解率高于比例数高者治疗缓解率 ,但均无显著性差异 (P>0 .0 5 )。结论 :患者年龄、初诊时 WBC、L DH、外周血及 BM中原始 +(早 )幼稚细胞比例数均为 ANL L治疗缓解率的相关因素。
Objective: To analyze the correlative factors of remission rate of newly diagnosed adult acute non-lymphocytic leukemia (AL L). Methods: The t-test and chi-square test for various factors were statistically processed. Results: Compared with WBC> 50 × 10 9 / L group, the number of peripheral blood leukocytes (WBC) <2 0 × 10 9 / L group and WBC 2 0 × 10 9 / L ~ 5 0 × 10 9 / (P <0.01 and P <0.05). According to the value of lactate dehydrogenase (L DH) in the serum at the first diagnosis, the CR and PR, CR and NR There was a significant difference between groups (P <0.01). The response rate of low age group (16-55 years old) was higher than that of high age group (> 54 years old) (61.4%). The initial rate of remission in peripheral blood and bone marrow (BM) + (Early) proportion of naive cells was lower than the proportion of patients with higher than the proportion of treatment response rate, but no significant difference (P> 0.05). CONCLUSION: The age, initial WBC, L DH, peripheral blood and the ratio of naive + (early) naive cells in BM are the related factors of ANL L response rate.