A large-scale compressor set of a 2 kW helium cryoplant, as one of the subsystems ofEAST (the experimental advanced superconducting tokamak), is arranged in a two-stage series-parallel structure. A fully automatic control system used to handle the compressors’ on/off/scheduling and the pressures’ adjustment was developed. To reduce the long time lag and theuncertainty with the energy slide valves effectively, expert rules in combination with proportional-integral-derivative (PID) algorithms were applied. Safety protection and status analysis mecha-nisms were built up to reinforce its stability and robustness. The new system has been appliedto the EAST operations and is operated stably. The problems in the previous semi-automaticsystem, such as the big overshoot of pressure and complexity of the operations, were solved. A large-scale compressor set of a 2 kW helium cryoplant, as one of the subsystems of EAST (the experimental advanced superconducting tokamak), is arranged in a two-stage series-parallel structure. A fully automatic control system used to handle the compressors’ to reduce the long time lag and the unicentty with the energy slide valves effectively, expert rules in combination with proportional-integral-derivative (PID) algorithms were applied. Safety protection and status analysis The new system has been applied to the EAST operations and is operated stably. The problems in the previous semi-automobile system, such as the big overshoot of pressure and complexity of the operations, were solved.