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目的:通过荷瘤小鼠高架十字迷宫实验,观察扶脾抑肝清心方药的抗焦虑作用。方法:连续给予扶脾抑肝清心方药14天后,进行高架十字迷宫实验。记录动物的OE、CE、OT和CT等指标。结果:扶脾抑肝清心方药等效及高剂量均能提高高架十字迷宫荷瘤小鼠的OE+CE、OE/(OE+CE)、OT/(OT+CT),并存在一定的量效关系,其中等效剂量组的效果最好。结论:扶脾抑肝清心方具有明显的抗焦虑作用,且以等效剂量效果最佳。
OBJECTIVE: To observe the anti-anxiety effects of Fupi Qinggan Xinxin Recipe by using an elevated cross-maze experiment in tumor-bearing mice. METHODS: Fourteen days after continuous administration of Spleen-inhibiting Liver Qingxin Recipe, an elevated plus-maze experiment was performed. Animal OE, CE, OT and CT were recorded. RESULTS: Efficacy and high dose of Fupi Qingganxinxin prescription could increase OE+CE, OE/(OE+CE) and OT/(OT+CT) in tumor-bearing mice with elevated cross-maze, and there was a certain dose effect. Relationships, in which the equivalent dose group performed best. Conclusion: Fupi Qinggan Qingxin Decoction has obvious anti-anxiety effect, and the effect of equivalent dose is the best.