钙调磷酸酶抑制剂如环孢素A和他克莫司可通过减少一氧化氮和前列腺素、增加内皮素和血栓素A2引起内皮功能障碍,进而影响肾小球小动脉的收缩,降低肾小球滤过率。长期作用下,钙调磷酸酶抑制剂可以导致肾小管萎缩、肾间质纤维化和动脉硬化。心血管疾病是影响肾移植患者病死率重要 Calcineurin inhibitors such as cyclosporine A and tacrolimus can cause endothelial dysfunction by decreasing nitric oxide and prostaglandins, increasing endothelin and thromboxane A2, thereby affecting glomerular arteriolar contraction and lowering renal Ball filtration rate. Long-term effects, calcineurin inhibitors can lead to tubular atrophy, interstitial fibrosis and atherosclerosis. Cardiovascular disease is important in affecting mortality in kidney transplant patients