论文部分内容阅读
目的探讨心肌肌钙蛋白I(cTnI)变化对诊断系统性红斑狼疮(SLE)心脏损伤的临床意义及其与病情活动的关系。方法应用Beckman Coulter Access Immunoassay System2对SLE合并心力衰竭患者、SLE无心力衰竭患者和健康人血清cTnI水平进行测定,用SLE活动指数积分评价SLE患者病情活动情况。结果SLE心力衰竭组血清cTnI增高,与无心力衰竭组的差异有统计学意义;无心力衰竭组血清cTnI与健康对照组的差异无统计学意义。血清cTnI的变化与SLE病情活动指数无相关性;其变化与病程有相关性。结论SLE合并心力衰竭时有心肌损伤存在,提示预后较差,治疗时应加强保护心肌。
Objective To investigate the clinical significance of cardiac troponin I (cTnI) changes in the diagnosis of systemic lupus erythematosus (SLE) heart injury and its relationship with disease activity. Methods Serum levels of cTnI in patients with SLE complicated with heart failure, patients with heart failure without SLE and healthy individuals were determined by Beckman Coulter Access Immunoassay System2. SLE activity index score was used to evaluate the status of disease activity in patients with SLE. Results The serum levels of cTnI in patients with SLE heart failure were significantly higher than those without heart failure. There was no significant difference in the serum levels of cTnI between the patients without heart failure and the healthy controls. Serum cTnI changes and SLE disease activity index no correlation; its change and duration of a correlation. Conclusions Myocardial injury exists in patients with SLE complicated with heart failure, suggesting that the prognosis is poor. Myocardial protection should be strengthened during the treatment.