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近年来,基因工程学的发展,有可能大量使用肿瘤坏死因子(TNF)的纯品,有利于开展TNF的基础研究和探讨其有关生理意义。过去认为TNF仅对肿瘤细胞有作用,但是它对许多正常细胞也起作用,其生物学活性是多样的。本文概述其最新研究进展。 TNF是将脂多糖(LPS)静注于卡介苗致敏的小鼠,血清中产生的一种物质,经注入皮下移植Meth A肉瘤的小鼠体内,可使肉瘤组织出血坏死,故而得名。TNF是巨噬细胞/单核细胞产生的一种蛋白质,由于它在体外可以直接杀伤某种肿瘤细胞,而对正常细胞则无影响,因此有希望作为抗肿
In recent years, the development of genetic engineering, it is possible to use a large number of pure tumor necrosis factor (TNF), is conducive to carry out the basic research on TNF and explore its physiological significance. It has been thought that TNF acts only on tumor cells in the past, but it also acts on many normal cells, and its biological activity is diverse. This article outlines the latest research progress. TNF is lipopolysaccharide (LPS) intravenous injection of BCG-sensitized mice, a substance produced in serum injected into the subcutaneous Meth A sarcoma mice can make hematogenous sarcoma necrosis, so named. TNF is a protein produced by macrophages / monocytes. Since TNF can directly kill certain tumor cells in vitro and has no effect on normal cells, it is promising as an anti-swollen