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２１只体重２．５～３．０ｋｇ的新西兰白兔用于研究牙种植体植入后的早期新骨形成。钛合金种植体植入胫骨干骺端的前内侧面。术后每周分别给动物注射四环素、二甲酚橙和茜草素络合酮以标记新骨。结果表明种植体植入后可引起其邻近部分骨坏死、吸收，然后出现新骨形成和改建。在４２ｄ的标本中可见部分直接的骨＿种植体接触。新骨中的矿物沉积率及实验早期的矿物沉积率较高。
Twenty-one New Zealand white rabbits weighing 2.5-3.0 kg were used to study early new bone formation after implantation of dental implants. Titanium implants implanted into the anterior medial aspect of the tibial metaphysis. Animals were injected with tetracycline, xylenol orange and malathion complex ketones weekly to mark new bone. The results showed that implants could cause the adjacent part of the bone necrosis, absorption, and then new bone formation and remodeling. In the 42d specimens visible partial direct bone-implant contact. The new bone mineral deposition rate and early experimental mineral deposition rate higher.