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①目的 了解白细胞介素－６（ＩＬ－６）在急性心肌梗死（ＡＭＩ）溶栓与非溶栓时的浓度变化，探讨其在ＡＭＩ发病过程中的作用。②方法 选择３０ 例发病１２ｈ 内入院的ＡＭＩ病人，其中１３ 例于发病后１２ｈ 溶栓成功，８ 例溶栓未通，９ 例未予溶栓治疗，用酶联免疫吸附法（ＥＬＩＳＡ）测定ＡＭＩ病人发病后１２，２４，４８，７２ 及１２０ｈ 时的ＩＬ－６浓度，并与１５例健康人进行比较。入院后２８ｄ 行多普勒检查测定左室射血分数（ＬＶＥＦ）。③结果 ３０ 例ＡＭＩ病人发病后１２，２４，４８，７２ 及１２０ｈ 的ＩＬ－６ 浓度均增高，与对照组相比较差异均有极显著意义（ｔ＝ ４．２０～６．２８，Ｐ 均＜０．０１），溶栓再通组１２，４８ｈ 时ＩＬ－６ 浓度与溶栓未通组和未溶栓组比较差异有极显著性（ｔ＝ ３．４２～４．７１，Ｐ＜ ０．０１）。ＩＬ－６ 浓度峰值与肌酸磷酸激酶（ＣＰＫ）、ＬＶＥＦ无相关性（ｒ＝ ０．２１，－ ０．３１，Ｐ＞ ０．０５）。④结论 ＩＬ－６ 参与ＡＭＩ发病和心肌缺血－再灌注的过程，检测ＩＬ－６ 浓度对判断冠状动脉是否再通有一定作用。
Objective To investigate the concentration of interleukin-6 (IL-6) in thrombolytic and non-thrombolytic therapy of acute myocardial infarction (AMI) and its role in the pathogenesis of AMI. Methods Thirty patients with AMI who were hospitalized within 12 hours after onset of onset were selected. Thirteen cases were successfully thrombolyzed at 12 hours after onset, 8 cases failed to pass thrombolysis and 9 cases received no thrombolysis. ELISA was used to measure AMI IL-6 concentrations at 12, 24, 48, 72 and 120 h after onset were compared with those in 15 healthy subjects. The left ventricular ejection fraction (LVEF) was measured by Doppler 28 days after admission. ③ Results The IL-6 concentrations of 12 AMI patients at 12, 24, 48, 72 and 120 hours after onset were significantly higher than those of the control group (t = 4.20 ~ 6.28, P < 0.01). There was a significant difference of IL-6 concentration between thrombolytic group and untreated group at 12,48h (t = 3.42 ~ 4.71, P <0. 01). The peak of IL-6 concentration had no correlation with creatine phosphokinase (CPK) and LVEF (r = 0.21, -0.31, P> 0.05). Conclusion IL-6 is involved in the pathogenesis of AMI and myocardial ischemia-reperfusion, and the detection of IL-6 concentration may play a role in determining whether the coronary artery recanalizes.