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化疗包括术前化疗(新辅助化疗)和术后化疗,是乳腺癌综合治疗的重要组成部分,然而并非所有患者对化疗敏感。近年来,有研究指出,除肿瘤细胞本身以外,肿瘤间质成分的特性也会影响新辅助化疗的疗效。这些特性包括局部免疫细胞、基质成纤维细胞以及肿瘤蛋白、基因组学指标等。相关研究为新辅助化疗方案的选择及提高疗效提供了新的途径。本文就这些方面进行了系统文献复习和总结。
Chemotherapy, including preoperative chemotherapy (neoadjuvant chemotherapy) and postoperative chemotherapy, is an important part of the comprehensive treatment of breast cancer, however, not all patients are sensitive to chemotherapy. In recent years, studies have pointed out that, in addition to the tumor cells themselves, the characteristics of the tumor interstitial components will also affect the efficacy of neoadjuvant chemotherapy. These features include local immune cells, stromal fibroblasts and tumor proteins, genomics and more. Related research has provided a new way for the selection of neoadjuvant chemotherapy regimens and the improvement of curative effect. This article reviews and summarizes the systematic literature on these aspects.