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目的初步探讨女性生殖道局部免疫与非淋菌性尿道炎(NGU)临床过程的相互关系。方法定量采集不同临床过程的NGU女性患者宫颈分泌物,检测分泌性免疫球蛋白A(SIgA)和γ干扰素(IFN-γ)的水平,分组比较。结果NGU感染组SIgA和IFN-γ的水平低于未感染组。NGU感染者中,沙眼衣原体(CT)感染组、解脲支原体(UU) 感染组和CT+UU合并感染组SIgA和IFN-γ水平没有显著性差异。NGU转阴组和未转阴组SIgA和IFN-γ水平无显著性差异,但从整体趋势上看,转阴组高于未转阴组。结论宫颈分泌物中的SIgA和IFN-γ对预防局部NGU感染有一定作用, 有助十清除局部病原菌。但SIgA和IFN-γ的局部免疫作用不强,不足以彻底清除病原体及预防再感染的发生。
Objective To investigate the relationship between the local immunization of female genital tract and the clinical course of non-gonococcal urethritis (NGU). Methods Cervical secretions of NGU women with different clinical course were collected quantitatively. The levels of SIgA and IFN-γ were measured and compared in groups. Results The levels of SIgA and IFN-γ in NGU-infected group were lower than those in non-infected group. There was no significant difference in the levels of SIgA and IFN-γ in NGU infected patients with CT infection, UU infection and CT + UU infection. There was no significant difference in the levels of SIgA and IFN-γ between NGU negative and negative control groups, but the overall negative trend was higher in negative control group than in negative control group. Conclusion SIgA and IFN-γ in cervical secretions play a role in preventing local NGU infection, which helps to eliminate local pathogenic bacteria. However, SIgA and IFN-γ local immunization is not strong, not enough to completely clear the pathogen and prevent the occurrence of re-infection.