论文部分内容阅读
本文用放射免疫法测得兔动脉壁亮氨酸脑啡肽(L-ENK)和甲硫氨酸脑啡肽(M-ENK)的含量(单位为Pg/mg组织湿重)分别是:耳动脉38.99±17.29,134.67±8.11,肾动脉31.10±7.76,93.60±18.22;肠系膜动脉25.70±13.60,88.43±18.16。动物经注射6-OHDA后,ENK含量显著下降,经利血平化后则无明显变化。用免疫组化PAP法观察到豚鼠肠系膜动脉外膜有L-ENK和M-ENK样免疫反应阳性纤维,手术摘除肠系膜神经节或注射6-OHDA,均可使ENK样免疫反应阳性纤维消失。结果表明,动脉壁内源性ENK位于支配该血管的交感神经纤维和末稍中,可能起着神经调制质的作用。
The content of L-ENK and M-ENK in rabbit arterial wall measured by radioimmunoassay in this paper were as follows: the ear (Pg / mg wet weight of tissue) Arteries 38.99 ± 17.29,134.67 ± 8.11, renal artery 31.10 ± 7.76,93.60 ± 18.22; mesenteric artery 25.70 ± 13.60,88.43 ± 18.16. After injection of 6-OHDA, the content of ENK decreased significantly in the animals and no significant change was observed after reserpine treatment. Immunohistochemical PAP method was used to observe the presence of L-ENK and M-ENK-like immunoreactive fibers in the mesenteric artery adventitia of guinea pigs. Enucleation of the mesenteric ganglion or injection of 6-OHDA resulted in the disappearance of ENK-like immunoreactive fibers. The results suggest that endogenous ENK in the arterial wall is located in the sympathetic nerve fibers and terminals that dominate this blood vessel and may play a neuromodulatory role.