患者，女性，４５岁。因双下肢肿胀１０月，加重伴怕热、多汗，心悸４月入院。病初无明显诱因出现双足背水肿，逐步向小腿蔓延，压之不凹陷，伴双眼睑浮肿。院外诊为“肾炎，风湿病”，服中西药无效。于４月前出现怕热、多汗、心悸、伴食欲亢进、消瘦、大便次数增多，双膝肿胀 Patient, female, 45 years old. Due to swelling of both lower extremities in October, increased with fear of heat, sweating, heart palpitations in April admission. Disease early no obvious incentive to appear dorsal edema, and gradually spread to the lower leg, pressure is not depressed, with double eyelid edema. Out-patient clinic as “nephritis, rheumatism”, serving Chinese and Western medicine is invalid. 4 months ago appeared afraid of heat, sweating, heart palpitations, with appetite hyperthyroidism, weight loss, increased stool frequency, swelling of both knees