1976年Miller提出,环境中的大多数致癌物须在细胞内经混合功能氧化酶的氧化激活,才能成为有亲电子性能的终致癌物;后者再与DNA、RNA及蛋白质的亲核部位共价结合。一旦造成DNA损伤,可以引起基因突变或基因调控异常,最终使细胞发生癌变。这个论点使人们对种类繁多, Miller proposed in 1976 that most carcinogens in the environment must be oxidized and activated by mixed-function oxidases in cells to become the ultimate carcinogen with electrophilic properties; the latter is then covalent with the nucleophilic sites of DNA, RNA, and proteins. Combine. Once it causes DNA damage, it can cause gene mutations or abnormal gene regulation, eventually causing the cells to become cancerous. This argument makes people have a great variety of