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目的 探讨白三烯 (LT)与运动性哮喘 (EIA)的关系。方法 测定 2 2例EIA患者与 10例正常对照组运动前和运动后 2h尿液中LTE4浓度。并对 12例EIA患者给予白三烯受体 (LTR)拮抗剂治疗。观察下述指标 :(1)用药前后运动后 1h内 1秒种用力呼气容积 (FEV1)下降与时间形成的曲线下面积AUC0 60min;(2 )用药前后运动后FEV1恢复至运动前FEV1± 5 %所需时间 ;(3)用药前后运动后FEV1下降的最大程度。结果 EIA组运动后尿液中LTE4浓度明显高于运动前 ,P <0 0 1,运动前与运动后 2hEIA组尿液中LTE4浓度均明显高于正常对照组 ,P <0 0 1。 12例EIA患者服用LTR拮抗剂扎鲁司特后 ,运动后 1h内FEV1下降与时间形成的曲线下面积AUC0 60min、运动后FEV1恢复至运动前时间、运动后FEV1下降的最大程度与用药前比较均明显减轻。结论 EIA患者运动后尿液中LTE4浓度明显升高 ,LTR拮抗剂能减轻EIA的程度。提示LT在EIA的发生中起到重要作用
Objective To investigate the relationship between leukotrienes (LT) and exercise-induced asthma (EIA). Methods Twenty-two EIA patients and 10 normal controls were used to measure the concentration of LTE4 in urine before and 2 hours after exercise. Twelve patients with EIA were treated with LTR antagonist. The following indexes were observed: (1) The area under the curve of 1-second forced expiratory volume (FEV1) decrease with time in 1h after exercise was 60min; (2) FEV1 before and after exercise was restored to FEV1 ± 5 % Of the time required; (3) before and after exercise the maximum extent of FEV1 decline. Results The urinary excretion of LTE4 in EIA group was significantly higher than that before exercise (P <0.01). The concentrations of LTE4 in urine before and 2 hours after exercise in EIA group were significantly higher than those in normal control group (P <0.01). After taking LTR antagonist zafirlukast in 12 patients with EIA, the area under the curve of FEV1 decline and time within 1h after exercise was AUC060min, after exercise, FEV1 returned to pre-exercise time, and the maximum extent of FEV1 decreased after exercise compared with before treatment Significantly reduced. Conclusion The concentration of LTE4 in urine of patients with EIA increased significantly after exercise, and LTR antagonist could reduce the extent of EIA. Tip LT plays an important role in the occurrence of EIA