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一般认为糖皮质激素(GC)治疗肾小球疾病是通过抗炎和抑制免疫途径实现的,但确切的机制并不十分清楚,近年来由于糖皮质激素受体(GR)基础研究的深入,已基本阐明了该作用的受体机制,文献认为[1]:GC与靶细胞胞浆内GR结合是GC发挥效应的先决条件,GC-GR复合物与核内靶基因附近的GC反?
Glucocorticoid (GC) treatment of glomerular disease is generally believed to be achieved through anti-inflammatory and anti-immune pathways, but the exact mechanism is not well understood. In recent years, due to the basic research of glucocorticoid receptor (GR) Basically elucidated the receptor mechanism of this role, the literature that [1]: GC and target cells in the cytoplasmic GR binding is GC prerequisite for the effect of the prerequisite for the GC-GR complex and nuclear target genes near the GC?