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目的：观察低压缺氧治疗哮喘的疗效。方法：选用轻一中度哮喘缓解期病人２７例，在低压舱内进行间断低压缺氧治疗１０天，观察其治疗效果，检测血浆皮质醇和血清可溶性白介素２受体（ｓＩＬ－２Ｒ）的变化，比较肺功能改变。结果：（１）哮喘病人治疗后随访显示，发作间歇延长和用药减少，有效率达８８．９％；（２）肺功能变化：治疗后肺功能明显改善，最大呼气流速（ＰＥＦ）明显增加（ Ｐ＜ ０．０１），第一秒用力呼气容量（ＦＥＶ_１）明显增加（Ｐ＜ ０．０５），治疗后血浆皮质醇明显提高（ Ｐ＜ ０．０１）， ｓＩＬ－ ２Ｒ明显减少（ Ｐ＜ ０．０１），且ｓＩＬ－２Ｒ与皮质醇的变化呈显著负相关（ｒ＝－０．８５０４，Ｐ＜０．０１）。结论：低压缺氧治疗哮喘病人是有效的，其临床症状和肺功能改善，可能系低氧、低空气密度和内源性皮质醇水平升高作用的结果。
Objective: To observe the effect of hypobaric hypoxia on asthma. Methods: Twenty-seven patients with mild to moderate asthma at remission stage were treated with intermittent hypobaric hypoxia for 10 days in low pressure cabin. The therapeutic effect was observed. The changes of plasma cortisol and soluble interleukin 2 receptor (sIL-2R) Compare lung function changes. Results: (1) The follow-up of patients with asthma showed intermittent prolongation of seizure and medication reduction, the effective rate was 88.9%. (2) The changes of pulmonary function: The pulmonary function improved obviously and the maximum expiratory flow rate (PEF) (P <0.01), forced expiratory volume in the first second (FEV_1) significantly increased (P <0.05), plasma cortisol significantly increased (P <0.01) and sIL- <0.01). There was a significant negative correlation between sIL-2R and cortisol (r = -0.8504, P <0.01). Conclusion: Hypobaric hypoxia is effective in the treatment of asthmatic patients. The clinical symptoms and pulmonary function are improved, which may be the result of hypoxia, low air density and elevated endogenous cortisol levels.