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目的探讨中老年人群血清尿酸与胰岛素分泌及其敏感性之间的关系。方法检测574例中老年人群和相关临床指标,分析高尿酸男性(尿酸≥417μmol/L,71例)、高尿酸女性(尿酸≥357μmol/L,29例)和尿酸正常者(男262例,女212例)血清尿酸水平与胰岛素相关性指标的关系。结果女性人群中高尿酸者肌酐(Cr)、胰岛素、C-肽、胰岛素释放指数(INSR30、INSR120)均高于尿酸正常者,Matsuda胰岛素敏感性指数(Matsuda ISI)低于尿酸正常者(P<0.05或P<0.01);而在男性人群高尿酸者Cr水平高于尿酸正常者,Matsuda ISI水平低于尿酸正常者(P<0.05或P<0.01)。多重线性回归分析显示,女性人群中血清尿酸与INSR30、INSR120存在线性回归关系(P<0.05),而男性人群无线性回归关系(P>0.05)。结论女性人群血清尿酸与胰岛素分泌及其敏感性比男性更具有相关性。
Objective To explore the relationship between serum uric acid and insulin secretion and its sensitivity in middle-aged and elderly people. Methods A total of 574 middle-aged and elderly patients and related clinical data were analyzed. The prevalence of hyperuricemic male (uric acid≥417μmol / L, 71 cases), hyperuricemic female (uric acid≥357μmol / L, 29 cases) and normal uric acid 212 cases) serum uric acid levels and insulin-related indicators. Results The levels of creatinine (Cr), insulin, C-peptide and insulin release index (INSR30, INSR120) were significantly higher in women with high uric acid than those with normal uric acid (Matsuda ISI) Or P <0.01). In the male population, the level of Cr in high uric acid group was higher than that in uric acid group, and the Matsuda ISI level was lower than that in uric acid group (P <0.05 or P <0.01). Multiple linear regression analysis showed that there was a linear regression relationship between serum uric acid and INSR30 and INSR120 in female population (P <0.05), but there was no linear regression between male and female population (P> 0.05). Conclusion Serum uric acid, insulin secretion and their sensitivity in female population are more relevant than those in male.