论文部分内容阅读
目的:了解高原缺氧环境对施工人员肝功能的影响。方法:选择进入海拔4500m施工(3~6)个月的施工人员221名,年龄(23~42)岁,工前体检正常,无临床症状,HBSAg(-),空腹抽静脉血采用《全国临床检验操作规程》中的改良赖氏法查肝功。结果:受检221人,异常45人,异常率20.3%,谷丙转氨酶均值(83.76±9.23)U/L,而且不同海拔施工人员均明显高于管理人员(P<0.01);施工前、中、后相比,有显著差别(P<0.01),呈先高后低的趋势;4500m海拔的管理人员和施工人员异常率均高于低海拔同类人员(P<0.01)。结论:高原低氧环境可引起肝脏机能和代谢方面的改变,并与低氧程度成正比;而且随在高原生活时间的延长,这种异常变化也随之降低。另外还可能与劳动强度、个体差别以及肝功能试验的敏感性和实验方法等有关,其根本原因尚有待于进一步研究。
Objective: To understand the impact of altitude hypoxia on the liver function of construction workers. Methods: A total of 221 construction workers (aged from 23 to 42) were enrolled in the 4500m altitude construction (3-6 months). The physical examination before work was normal and no clinical symptoms were found. HBSAg (- Inspection Practice "in the improvement of Lai’s method of liver function. Results: 221 subjects were examined, 45 were abnormal, the abnormality rate was 20.3%, and the mean alanine aminotransferase (83.76 ± 9.23) U / L was also found. The construction workers at different altitudes were significantly higher than those at management (P <0.01) (P <0.01). The abnormal rate of managers and constructors at 4500m above sea level were higher than those at the same altitude (P <0.01). CONCLUSION: The plateau hypoxia environment can cause changes in liver function and metabolism, and is proportional to the degree of hypoxia. With the prolonging of the plateau life, this abnormal change also decreases. In addition may also be related to labor intensity, individual differences and the sensitivity of liver function tests and experimental methods, the root cause remains to be further studied.