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目的探索红细胞内Ca2+、肺动脉平滑肌细胞内Ca2+水平与肺动脉高压的关系。方法采用流式细胞术分别检测先天性心脏病合并肺动脉高压的患儿18例、先天性心脏病未合并肺动脉高压的患儿19例红细胞内钙离子含量及肺动脉平滑肌细胞钙含量。结果红细胞钙与肺动脉平滑肌细胞钙呈正相关关系,相关系数为γ=0.818(P<0.01)。结论改善先心病病人的钙离子浓度可以有效的降低PH的发生率。
Objective To explore the relationship between Ca2 + in erythrocytes and intracellular Ca2 + in pulmonary artery smooth muscle cells and pulmonary hypertension. Methods 18 cases of children with congenital heart disease complicated with pulmonary hypertension and 19 cases of children with congenital heart disease without pulmonary hypertension were respectively examined for erythrocyte calcium content and calcium content in pulmonary artery smooth muscle cells by flow cytometry. Results There was a positive correlation between calcium in erythrocytes and calcium in pulmonary artery smooth muscle cells. The correlation coefficient was γ = 0.818 (P <0.01). Conclusion To improve the calcium concentration in patients with congenital heart disease can effectively reduce the incidence of PH.