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目的探讨影响乳腺癌保乳手术后局部复发的预后因素。方法对中国医学科学院肿瘤医院腹部外科2001年1月至2004年12月间收治的175例早期乳腺癌保乳手术资料进行回顾性研究,对年龄、分期、切缘、肿瘤大小、淋巴结情况等指标做单因素和多因素分析。结果中位随访时间57(18～94)个月。全组5年的总存活率和无病存活率分别为96.4%和91.1%,局部复发率1.7%。单因素分析显示保乳手术后局部复发危险因素包括肿瘤直径>3 cm、切缘<2mm以及TNM分期。结论早期乳腺癌行保乳治疗是安全的,但要掌握保乳手术指征,保证术后综合治疗。
Objective To investigate the prognostic factors affecting the local recurrence after breast-conserving surgery in breast cancer. Methods A retrospective study was conducted on the data of 175 cases of breast conserving surgery treated by the Department of Abdominal Surgery, Cancer Hospital of Chinese Academy of Medical Sciences between January 2001 and December 2004. The data of age, staging, tumor margins, tumor size and lymph node status Do single factor and multivariate analysis. Results The median follow-up time was 57 (18-94) months. The overall 5-year overall survival and disease-free survival rates were 96.4% and 91.1%, the local recurrence rate of 1.7%. Univariate analysis showed that risk factors for local recurrence after breast conserving surgery included tumor diameter> 3 cm, cut edge <2 mm, and TNM staging. Conclusion Breast-conserving therapy is safe in early breast cancer. However, indications for breast-conserving surgery should be grasped to ensure postoperative comprehensive treatment.