对维生素D的耐受性各人不同,有的人可以耐受大量维生素D,不会发生中毒,有的人对维生素D过敏和耐受不良,应用大量维生素D可产生不良症状,这就是维生素D过多症。此病系1952年Lightwood和Payne在英国首先描述,他们发现了一组原因不明的婴儿高钙血症,同年Fanconi报告了此病的严重型。此后4年英国报告已超过200例,西欧和北美其他国家也有病例报告,当时婴儿广泛应用含维生素D强化的奶粉喂养,维生素D增加了奶粉中钙的吸收,据调查当时英国奶粉中维生素D含量高,婴儿每日维生素D摄入量超过4000国际单位,故本病发病率高,1957～1958年将奶粉中维生素D含量减少了一半,间隔2～3年后,此病即显著减少,故认为与维生素D过 Resistance to vitamin D varies from person to person, some people can tolerate large amounts of vitamin D, does not occur poisoning, some people are allergic to vitamin D and poor tolerance, the application of large amounts of vitamin D can produce adverse symptoms, which is vitamins D too much disease. The disease was first described by Lightwood and Payne in the United Kingdom in 1952 when they found a group of infants with an unknown cause of hypercalcaemia and the same year Fanconi reported a severe form of the disease. In the following 4 years, there are more than 200 cases reported in Britain and other western and North American countries. Case reports were also made when babies were infused with vitamin D-fortified milk powder and vitamin D increased the calcium absorption in milk powder. According to the survey, the vitamin D content High, the daily intake of vitamin D infants over 4000 international units, so the incidence of the disease is high, from 1957 to 1958 the vitamin D content in milk reduced by half, an interval of 2 to 3 years later, the disease is significantly reduced, so Think with vitamin D too