利用铜催化的点击反应合成了侧链接枝DNA的聚多肽,基于DNA自组装的理念,将含有两段鸟嘌呤(G)的序列引入到体系中,结合G-四联体在钾离子存在的情况下能够形成分子间四链结构的特性,获得了具有热响应和离子响应性的聚多肽-DNA超分子水凝胶.此凝胶制备过程具有原位、快速等特点,构筑基元具有可设计的响应性和良好的生物相容性.综合以上特点,此超分子水凝胶在组织工程和三维生物打印等领域具有潜在的应用. Based on the idea of ​​DNA self-assembly, a poly-peptide with side-chain grafted DNA was synthesized by copper-catalyzed click reaction. The sequence containing two guanine (G) sequences was introduced into the system. Can form the characteristics of the four-chain structure between molecules and obtain the poly-peptide-DNA supramolecular hydrogel with thermal response and ion response. The preparation process of the gel has the advantages of in-situ and fast, Design responsiveness and good biocompatibility.According to the above characteristics, this supramolecular hydrogel has potential applications in the fields of tissue engineering and three-dimensional bio-printing.