论文部分内容阅读
目的：探讨十二指肠球部溃疡（DU）患者长程疗效。方法：对90例Hp阳性的十二指肠球部溃疡病人，给予不同方案治疗，并进行12～18个月长程疗效追踪观察，定期复查胃镜，取胃粘膜组织进行病理学检查，细菌培养及14C－尿素呼吸试验，了解溃疡愈合情况及Hp根除状况。结果：即根除组中溃疡复发率为20．4％，累积再感染和再燃率为13．0％，部分溃疡复发者与服用非甾体消炎药、嗜酒有关，Hp未根除组溃疡复发率为69．4％，与根除组有显著差异（P＜0．005），且Hp根除组未见溃疡出血者。结论：Hp根除后溃疡复发率明显下降，与国外报告相比，我国DU患者Hp根除后再感染及再燃率略高。
Objective: To investigate the long-term efficacy of duodenal ulcer (DU). Methods: 90 cases of Hp-positive duodenal ulcer patients were given different treatment programs, and 12 to 18 months long-term follow-up observation, regular review of gastroscopy, gastric mucosa for pathological examination, bacterial culture and 14C-urea breath test to understand the healing of ulcers and Hp eradication. Results: In the eradication group, the ulcer recurrence rate was 20.4%, cumulative re-infection and reburning rate was 13.0%. Some ulcer recurrences were related to taking non-steroidal anti-inflammatory drugs and alcohol abuse. Hp non-eradication group ulcer recurrence rate Was 69.4%, there was significant difference with eradication group (P <0.005), and there was no ulcer bleeding in Hp eradication group. Conclusions: The recurrence rate of ulcer after Hp eradication decreased obviously. Compared with the foreign reports, the Hp eradication rate and the reburning rate of DU patients in our country were slightly higher.