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正常血管通透性的维持有赖于血管内皮细胞屏障的完整性,内皮细胞与内皮细胞间、细胞与基底膜间的连接以及胞内骨架蛋白收缩这3种力量,经蛋白质相互作用,在功能和调节上互相关联。烧伤休克的主要临床特点是低血容量性休克,其主要原因之一是毛细血管扩张,血管通透性增加,毛细血管静水压增加,促进了血浆样液体的渗出,导致血容量锐减。关于内皮细胞屏障功能在烧伤后血管通透性变化中的作用,我们近年来做了一些研究工作。
The maintenance of normal vascular permeability depends on the integrity of the barrier of vascular endothelial cells, endothelial cells and endothelial cells, the connection between cells and the basement membrane and the contraction of intracellular cytosolic these three forces through protein interactions in the function and Adjusted to each other. The main clinical feature of burn shock is hypovolemic shock, one of the main reasons is the telangiectasia, increased vascular permeability, increased capillary hydrostatic pressure, and promote the exudation of plasma-like liquid, resulting in a sharp decrease in blood volume . In the role of endothelial cell barrier function in the changes of vascular permeability after burn, we have done some research in recent years.