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红茴香 (Illicium lanceolatum A. C. Smith) 注射液(根皮,10％) 的半数致死量为70ml/kg (小白鼠,ip),其平均可信限为70±5.5ml/kg (P=0.95)。安全试验:对小白鼠按体重折算,以相当于200倍人用剂量的5％红茴香注射液,8ml/kg,ip,除出现扭体反应外,未见其它反应;对家兔,给以成人临床常用量的125倍,5ml/kg,由耳缘静脉推注、除该静脉呈青紫外,未见异常。对其余实验动物的血像 (血色素、红细胞计数、白细胞计数及分类)、肝功能 (麝香草酚浊度、硫酸锌浊度、谷丙转氨酶和电泳蛋白)、肾功能 (尿素氮) 和心电图检查,用药前后对比,都属正常范围。
The median lethal dose of Illicium lanceolatum A. C. Smith injection (root barks, 10%) was 70 ml/kg (rats, ip), with an average confidence limit of 70 ± 5.5 ml/kg (P = 0.95). Safety test: According to the body weight of mice, equivalent to 200 times the human dose of 5% red fennel injection, 8ml/kg, ip, in addition to writhing reaction, no other reaction; rabbits, given Adults commonly used 125 times the amount of clinical, 5ml/kg, by the injection of ear vein, in addition to the vein showed blue UV, no exception. Hemograms (hemoglobin, red blood cell count, white blood cell count and classification), liver function (thymol turbidity, zinc turbidity, alanine aminotransferase and electrophoretic protein), renal function (urea nitrogen), and electrocardiogram for the remaining experimental animals Before and after medication, the normal range.