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不同地区地方性砷中毒临床表现虽然不尽相同,但均以皮肤损伤、外周血管疾病、高血压等最为常见[1]。随着对砷研究的不断深入,发现砷化物对机体的损伤是从外周血管开始的,特别是对血管内皮细胞的损伤,在地方性砷中毒的发病机制中占有重要地位。研究显示,周围血管是砷毒作用的主要靶器官[2-4]。损伤血管获得及时修复是维持其完整性的决定因素[5],而健康的血管内皮细胞负责血管完整性的维持、损伤血管壁的修复及损伤组织血管的再建。所以,
Although the clinical manifestations of endemic arsenism in different areas vary, they are most commonly found in skin lesions, peripheral vascular diseases and high blood pressure [1]. With the deepening of research on arsenic, we found that arsenic damage to the body begins from the peripheral blood vessels, especially the damage of vascular endothelial cells, which plays an important role in the pathogenesis of endemic arsenism. Studies have shown that peripheral blood vessels are the main target organ of arsenic toxicity [2-4]. The timely repair of damaged blood vessels is a determinant of maintaining its integrity [5], while healthy vascular endothelial cells are responsible for the maintenance of vascular integrity, repair of injured vessel walls, and reconstruction of damaged tissue vessels. and so,