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导致肾移植术后第1年移植物丧失的最常见原因是急性排斥。然而,很少有人研究急性排斥对移植物后果及功能的影响。为此,他们从1987.6～1990.3对110例首次尸肾移植受者(年龄>10岁)随机分为三联组(Ⅰ组,53例)和四联组(Ⅱ组,57例)进行前瞻性分析。Ⅰ组免疫抑制方案:根据术后尿量,CsA3～4mg/kg.d青点,5天后按5mg/kg.db.i.d口服,头3个月保持CsA全血谷值浓度300～450ng/ml(RIA法),尔后保持100～250ng/ml。Ⅱ组起始应用ALG10mg/kg.d,当SCr<300μmol/L时按如上所
The most common cause of graft loss at 1 year after renal transplantation is acute rejection. However, few studies have investigated the effects of acute rejection on graft outcomes and function. To this end, they conducted a prospective analysis of 110 first-born renal transplant recipients (age> 10 years) from 1987.6 to 1990.3 randomly into triple groups (group I, n = 53) and quadruple groups (group II, n = 57) . Group Ⅰ immunosuppressive regimen: according to postoperative urine output, CsA3 ~ 4mg / kg.d green point, 5dmg 5d / d.d.id after 5 days, the first 3 months to maintain CsA whole blood trough concentration 300 ~ 450ng / ml (RIA method), then keep 100 ~ 250ng / ml. Group Ⅱ initial application of ALG10mg / kg.d, when the SCr <300μmol / L according to the above